A paper on the effects of nanosecond pulsed electric fields (nsPEFs) has been accepted for publication in Bioelectrochemistry journal. The paper was a result of collaboration between Prof. Juergen F. Kolb, Anna Steuer and Anke Schmidt at the Institute for Plasma Science and Technology, INP Greifswald (Germany), and RECETOX, Masaryk University (Czech Rep.), represented by Pavel Babica and Petra Labohá (a former postdoctoral researcher at Prof. Kolb's lab). The paper is the very first report on the modulations of gap junctional intercellular communication by nsPEFs, which is a very perspective tool being developed and tested for different biomedical applications, such as cancer therapy or wound healing. nsPEF treatments were inducing rapid, pronounced but reversible inhibition of GJIC in vitro accompanied by disassembly of connexin plaques and activation of mitogen-activated protein kinases. Modulations of GJIC by nsPEF might contribute to its biological effects, and could be utilized to further develop more efficient or specific nsPEF treatments. Steuer, A., Schmidt, A., Labohá, P., Babica, P., Kolb, J.F.* (2016): Transient suppression of gap junctional intercellular communication after exposure to 100-nanosecond pulsed electric fields. Bioelectrochemistry 112:33-46 UPDATE: Full-text PubMed Pavel BBC
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A new high school science project (SOČ - středoškolská odborná činnost) supervised by Ondra Brózman has been started in our labs. The project is supported by JCMM and focuses on the effects of brominated compounds in human pulmonary in vitro model ("Efekty bromovaných látek v in vitro modelu lidské dýchací soustavy"). The trainee for this project and our new intern is Klára Müllerová, a high school student from Gymnázium Řečkovice. Klára will be working with human bronchial epithelial cell line HBE1 to study effects of brominated compounds, which are used as flame retardants and represent important contaminants of indoor air.
We have also another trainee, Ondrej Kováč, who is a graduate student (M.Sc. candidate) from the Department of Biochemistry at Masaryk University. Ondrej will be working with us under the supervision of Honza Raška, focusing on the use of molecular biology tools to study mechanisms of cyanotoxin toxicity in liver in vitro models. Last month was very successful for SECANTOX bachelor and master students! Eliška Blažková, Tomáš Cimr and Zuzana Kolářová passed the state exams and successfully defended their bachelor theses and completed their bachelor's degrees in Ecotoxicology. In addition, Renata Škovroňová also completed the state exam and received B.Sc. degree. Finally, Hanka Klímová also passed the state exam, defended her diploma thesis and completed her master's degree in Ecotoxicology. Lots of congratulations and we wish you the best of luck in the future! In fact, Hanka Klímová will continue to work with us as a research assistant and we are looking forward to further collaboration!
Here you can find links to the theses defended: Eliška Blažková (2016): "In Vitro Testicular Toxicity Models" (Bachelor's thesis) Tomáš Cimr (2016): "Cytotoxicity assessment using spheroid cell cultures" (Bachelor's thesis) Zuzana Kolářová (2016): "Cyanotoxin removal in drinking water treatment plants" (Bachelor's thesis) Renata Škovroňová (2015): "Carcinogenic and anticarcinogenic effects of cyanobacterial metabolites" (Bachelor's thesis) Hanka Klímová (2016): "Cellular uptake and biotransformation of cyanobacterial toxins in mammalian cell cultures in vitro" (Master's thesis) UPDATE: Hanka Klímová's thesis has been awarded with the RECETOX Director's Award for the Best Diploma Thesis in 2016! Congratulations! |
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