Last week (May 16-19, 2017), Bára Kubíčková and Renata Škovroňová together with other colleagues from RECETOX (Marek Pípal, Zuzka Nováková) attended JRC Summer School on Alternative Approaches for Risk assessment in the Joint Research Centre (JRC) in Ispra, Italy, which focused on comprehensive training on state-of-the-art alternative (non-animal) approaches to predictive toxicology and their use within modern chemical risk assessment practice. The program was very interesting, covering exposure assessment, hazard identification and characterisation, in vitro methods and computational modelling, validation principles and practice, and analysis of uncertainty. Bára and Renata also presented their posters on the effects of cyanobacterial toxins in in vitro models of human airway or renal epithelial cells: Kubíčková et al.: Cultured immortalized human airway epithelial cells - an in vitro approach to study cylindrospermopsin inhalation toxicity. Škovroňová et al.: Nephrotoxic potential of cyanobacterial toxins – in vitro study.
Pavel BBC
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In the special issue, we published a paper reporting that ozonation of cyanobacterial extract effectively removes microcystins, microcystin-independent in vitro tumor promoting activity (inhibition of gap junctional intercellular communication, activation of mitogen activated protein kinases) as well as cytotoxicity. In contract, chlorination was much less effective in removing toxins and in vitro toxicity, even if high chlorine doses causing a similar level of total organic carbon reduction as ozone were applied. The study indicates advantages of ozonation as well as effect-based monitoring in evaluation of water treatment technologies. Sovadinová, I.*, Babica, P., Adamovský O., Alpatova, A., Tarabara, V., Upham, B., Bláha, L. (2017): Effects of chlorination and ozonization on epigenetic toxicity of cyanobacterial extracts. Advances in Oceanography and Limnology 8(1) (in press) Full-text (Open Access)
Stoyneva-Gaertner, M. P.*, Pavlova, V., Uzunov, B., Bratanova, Z., Descy, J.-P., Babica, P., Marsalek, B., Meriluoto, J., Spoof, L. (2017): Assessment of cyanoprokaryote blooms and of cyanotoxins in Bulgaria in a 15-years period (2000-2015). Advances in Oceanography and Limnology 8(1) Full-text (Open Access) Pavel BBC
Pavel BBC
Pavel BBC
A new study prepared by HEAR group at RECETOX (Anežka Sharma, Katarína Bányiová and Pavel Čupr) and their collaborators, including also Pavel Babica, has been published in Science of the Total Environment journal. The study has shown for the first time that photoisomerisation product cis-2-ethylhexyl 4-methoxycinnamate (cis-EHMC) formed by irradiation of a common sunscreen ingredient, trans-EHMC, is significantly more potent inducer of genotoxic damage in mammalian cells than the parental compound. These genotoxic effects were demonstrated not only in human lymphoblastoid TK-6 cells, but also in adult human liver stem cells HL1-hT1. Using QIVIVE modeling and probabilistic risk assessment, it has been demonstrated that cis-EHMC might represent up to 7-times higher health risk than trans-EHMC in selected populations, such as females.
During the first month of this year, there have been couple new events and changes in our group:
Pavel BBC
Pavel BBC
Veronika Musilová successfully defended her Master's degree thesis titled "Hepatotoxic and hepatocarcinogenic effects of chemicals in spheroid cell cultures" and passed the state exam. Congratulations and we are looking forward to continue our collaboration with Veronika Musilová, M.Sc., as a new Ph.D. student within our group! Pavel BBC
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