A new study prepared by HEAR group at RECETOX (Anežka Sharma, Katarína Bányiová and Pavel Čupr) and their collaborators, including also Pavel Babica, has been published in Science of the Total Environment journal. The study has shown for the first time that photoisomerisation product cis-2-ethylhexyl 4-methoxycinnamate (cis-EHMC) formed by irradiation of a common sunscreen ingredient, trans-EHMC, is significantly more potent inducer of genotoxic damage in mammalian cells than the parental compound. These genotoxic effects were demonstrated not only in human lymphoblastoid TK-6 cells, but also in adult human liver stem cells HL1-hT1. Using QIVIVE modeling and probabilistic risk assessment, it has been demonstrated that cis-EHMC might represent up to 7-times higher health risk than trans-EHMC in selected populations, such as females.
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